Home > Health/Pharma > A Step Toward Minute Factories That Produce Medicine Inside the Body

A Step Toward Minute Factories That Produce Medicine Inside the Body

ScienceDaily (June 27, 2012) — Scientists are reporting an advance toward treating disease with minute capsules containing not drugs — but the DNA and other biological machinery for making the drug. In an article in ACS’ journal Nano Letters, they describe engineering micro- and nano-sized capsules that contain the genetically coded instructions, plus the read-out gear and assembly line for protein synthesis that can be switched on with an external signal.

Scientists are reporting an advance toward treating disease with minute capsules containing not drugs — but the DNA and other biological machinery for making the drug. (Credit: © Benicce / Fotolia)
 
Daniel Anderson and colleagues explain that development of nanoscale production units for protein-based drugs in the human body may provide a new approach for treating disease. These production units could be turned on when needed, producing medicines that cannot be taken orally or are toxic and would harm other parts of the body. Until now, researchers have only done this with live bacteria that were designed to make proteins at disease sites. But unlike bacterial systems, artificial ones are modular, and it is easier to modify them. That’s why Anderson’s group developed an artificial, remotely activated nanoparticle system containing DNA and the other “parts” necessary to make proteins, which are the workhorses of the human cell and are often used as drugs.
 
 
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